Second-generation microarrays

EDITORIALS Tissue Microarrays for Hypothesis Generation

Decades of hypothesis-driven research have led to the discovery of oncogenes and tumor suppressors that affect carcinogenesis. With the advent of powerful genomic and proteomic microarray techniques, a different scientific paradigm is emerging—one in which hypotheses are generated based on the evaluation of global gene expression in cells or tissues. Tissue microarrays are also useful to interr...

Second-generation antidepressants.

"Second-generation" Skeleton Systems

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Second - Generation Wavelet

S eco n d-G e n eratio n Wa v elet C ollocatio n M eth o d for th e S olutio n of Partial Differe ntial E q u atio ns Oleg V. Vasilyev∗ and Christopher Bowman† ∗Department of Mechanical and Aerospace Engineering, University of Missouri–Columbia, Columbia, Missouri 65211; and †Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana 46556 E-mail: Vasilyev...

Second-harmonic generation

The goal of this experiment in nonlinear optics is to study the conversion of a (very small) fraction of laser light from its original wavelength of 980 nm (i.e. invisible to the naked eye) to its second-harmonic at a wavelength of 490 nm. This conversion takes place by mild focussing of an intense laser beam in a nonlinear birefringent crystal of BBO (= β BaBO4). You will study the physical pr...